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Additionally, 2-MCA inhibits glutamate dehydrogenase (GDH), reducing the conversion of glutamate to -ketoglutarate and thus restricting TCA cycle flux (Amaral et al

Optic-disk cupping is a consequence of myriad disorders, but in this case its reduction is evidently due to a reduced oxidative insult, which also produces a better control of cell homeostasis with consequent rescue of astrocytes and nerve fibers

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doi: 10.1089/dia.2006.8.677

Use with caution if you have autoimmune thyroid disease, and avoid during pregnancy

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